Buy Alloxan monohydrate (CAS ), a water soluble pyrimidine derivative & glucose analog. Join researchers using high quality Alloxan monohydrate. Alloxan monohydrate | C4H4N2O5 | CID – structure, chemical names, physical and chemical properties, classification, patents, literature, biological. Alloxan monohydrate (Sigma Aldrich, St. Louis, MO, USA; stored at 4°C) was dissolved in normal saline at room temperature and was injected by intraperitoneal.

Author: Mut Mezinris
Country: Montenegro
Language: English (Spanish)
Genre: Music
Published (Last): 4 December 2014
Pages: 135
PDF File Size: 3.77 Mb
ePub File Size: 20.42 Mb
ISBN: 932-4-99400-361-4
Downloads: 52434
Price: Free* [*Free Regsitration Required]
Uploader: Vushura

Alloxan was used in the production of the purple dye murexidediscovered by Carl Wilhelm Scheele in Brugnatelli called it ossieritrico erythric acid [p.

Create an account quickly and easily with your preferred social network account. Levi considers the droppings of pythons as a source for uric acid for making alloxan, but he is turned down by the director of the Turin zoo because the zoo already has lucrative contracts with pharmaceutical companies, so he is obliged to use chickens as his source of uric acid. Indian J Exp Biol Alloxan is named on p.

The synthesis fails, however, “and the alloxan and its resonant name remained a resonant name. Need more advice on solubility, usage and handling?

From Wikipedia, the free encyclopedia. Healthy adult albino rats g and rabbits 1. Alloxan induced diabetes in Such monohydrte responses with alloxan have also been reported by authors in the past. It was originally obtained by oxidation of uric acid by nitric acid. Moonohydrate is prepared by oxidation of barbituric acid by chromium trioxide.


Murexide results from the condensation of the unisolated intermediate uramil with alloxan, liberated during the course of the reaction. Generally, these will be monohydrafe for up to one month. Schocken,translated by Raymond Rosenthal, Hypoglycemic effects of vanadium on alloxan monohydrate induced diabetic dogs.

In diabetic rats and rabbits, random fluctuations in FBG with blood sugar returning to the nondiabetic range at various time periods during the study duration was observed. Furthermore, alloxan inhibits glucokinase, a SH-containing protein essential for insulin secretion induced by glucose.

The alloxan model of diabetes was first described in rabbits by Dunn, Sheehan and McLetchie in Send me a copy of this email. This product has been referenced in: Thank you for your question.

The Institutional Animal Ethics Committee approved the experimental protocol. Other names 5,5-Dihydroxybarbituric acid. Call us Toll Free at Our Cookie Policy explains how you can opt-out of wlloxan cookies we use. Alloxan is, however, toxic to the liver and the kidneys in high doses. PubMed used the cytotoxic compound Alloxan monohydrate to induce diabetes in Swiss albino mice.

Anomalies in alloxan-induced diabetic model: By using this site, you agree to the Terms of Use and Privacy Policy. However, we experienced an inconsistent and unpredictable response with alloxan, similar to that discussed by Jain et al. I recommend this reagent Date published: Alloxan monohydrate Sigma Aldrich, St.

Variations of susceptibility to alloxan induced diabetes in the rabbit. Your browser does not have JavaScript enabled and some parts of this website will not work without it. Alloxan is selectively toxic to insulin-producing pancreatic beta cells because it preferentially accumulates in beta cells through uptake via the GLUT2 glucose transporter.


Alloxan: An unpredictable drug for diabetes induction?

It is better to standardize it first. Author information Copyright and License information Disclaimer. Email address is required.

Your account has been deactivated.

Alloxan monohydrate | CAS | SCBT – Santa Cruz Biotechnology

For the best experience on the Abcam website please upgrade to a modern browser such as Google Chrome. You won’t have to remember an extra name and password. To place mononydrate order using RMB or to ship to mainland China, please visit www. I agree to the terms and conditions. This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3. Antidepressant-like effects of Brassica juncea L. Thus, with these fluctuations and unpredictable responses at any dose level, we were unable to derive any hypothesis about the hypoglycemic property of test compounds.

Already have an account? Gaspare Brugnatelli “Sopra i cangiamenti che avvengono nell’ ossiurico ac.